A small part of myosin IIB takes on a big role in cell polarity.

Fenix AM, Burnette DT
J Cell Biol. 2015 209 (1): 11-2

PMID: 25869662 · PMCID: PMC4395479 · DOI:10.1083/jcb.201503079

A migrating cell must establish front-to-back polarity in order to move. In this issue, Juanes-Garcia et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201407059) report that a short serine-rich motif in nonmuscle myosin IIB is required to establish the cell's rear. This motif represents a new paradigm for what determines directional cell migration.

© 2015 Fenix and Burnette.

MeSH Terms (5)

Animals Cell Polarity Humans Myosin Heavy Chains Nonmuscle Myosin Type IIB

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