Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design.

Burke JP, Bian Z, Shaw S, Zhao B, Goodwin CM, Belmar J, Browning CF, Vigil D, Friberg A, Camper DV, Rossanese OW, Lee T, Olejniczak ET, Fesik SW
J Med Chem. 2015 58 (9): 3794-805

PMID: 25844895 · PMCID: PMC5565203 · DOI:10.1021/jm501984f

MeSH Terms (11)

bcl-X Protein Crystallography, X-Ray Heterocyclic Compounds, 3-Ring Humans Indoles K562 Cells Models, Molecular Molecular Conformation Myeloid Cell Leukemia Sequence 1 Protein Protein Binding Structure-Activity Relationship

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