Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2.

Blobaum AL, Xu S, Rowlinson SW, Duggan KC, Banerjee S, Kudalkar SN, Birmingham WR, Ghebreselasie K, Marnett LJ
J Biol Chem. 2015 290 (20): 12793-803

PMID: 25825493 · PMCID: PMC4432295 · DOI:10.1074/jbc.M114.635987

MeSH Terms (9)

Animals Catalytic Domain Crystallography, X-Ray Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Mice Mutation, Missense Protein Binding Static Electricity

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