An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition.

Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC
Cell Rep. 2015 11 (1): 43-50

PMID: 25818300 · PMCID: PMC4394042 · DOI:10.1016/j.celrep.2015.03.001

MeSH Terms (14)

Animals Cyclic AMP-Dependent Protein Kinases Cyclic Nucleotide Phosphodiesterases, Type 4 Hedgehog Proteins Phosphodiesterase 4 Inhibitors Pyrimidinones Receptors, G-Protein-Coupled Signal Transduction Small Molecule Libraries Smoothened Receptor Thiophenes Transcriptional Activation Zebrafish Zebrafish Proteins

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