Peri-operative risk factors for delayed gastric emptying after a pancreaticoduodenectomy.

Robinson JR, Marincola P, Shelton J, Merchant NB, Idrees K, Parikh AA
HPB (Oxford). 2015 17 (6): 495-501

PMID: 25728447 · PMCID: PMC4430779 · DOI:10.1111/hpb.12385

BACKGROUND - Delayed gastric emptying (DGE) is a frequent cause of morbidity, prolonged hospital stay and readmission after a pancreaticoduodenectomy (PD). We sought to evaluate predictive peri-operative factors for DGE after a PD.

METHODS - Four hundred and sixteen consecutive patients who underwent a PD at our tertiary referral centre were identified. Univariate and multivariate (MV) logistic regression models were used to assess peri-operative factors associated with the development of clinically significant DGE and a post-operative pancreatic fistula (POPF).

RESULTS - DGE occurred in 24% of patients (n = 98) with Grades B and C occurring at 13.5% (n = 55) and 10.5% (n = 43), respectively. Using MV regression, a body mass index (BMI) ≥35 [odds ratio (OR) = 3.19], operating room (OR) length >5.5 h (OR = 2.72) and prophylactic octreotide use (OR = 2.04) were independently associated with an increased risk of DGE. DGE patients had a significantly longer median hospital stay (12 versus 7 days), higher 90-day readmission rates (32% versus 18%) and an increased incidence of a pancreatic fistula (59% versus 27%). When controlling for POPF, only OR length >5.5 h (OR 2.73) remained significantly associated with DGE.

CONCLUSIONS - DGE remains a significant cause of morbidity, increased hospital stay and readmission after PD. Our findings suggest patients with a BMI ≥35 or longer OR times have a higher risk of DGE either independently or through the development of POPF. These patients should be considered for possible enteral feeding tube placement along with limited octreotide use to decrease the potential risk and consequences of DGE.

© 2015 International Hepato-Pancreato-Biliary Association.

MeSH Terms (23)

Aged Body Mass Index Chi-Square Distribution Female Gastric Emptying Gastroparesis Humans Length of Stay Logistic Models Male Middle Aged Multivariate Analysis Odds Ratio Pancreatic Fistula Pancreaticoduodenectomy Patient Readmission Retrospective Studies Risk Factors Stomach Tennessee Tertiary Care Centers Time Factors Treatment Outcome

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