In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells.

Ratliff M, Alter S, McAvoy K, Frasca D, Wright JA, Zinkel SS, Khan WN, Blomberg BB, Riley RL
Aging Cell. 2015 14 (3): 382-90

PMID: 25727904 · PMCID: PMC4406667 · DOI:10.1111/acel.12302

MeSH Terms (9)

Animals Apoptosis Cell Cycle Checkpoints Cell Differentiation Immunoglobulin Light Chains, Surrogate Lymphocyte Activation Mice, Inbred C57BL Phosphorylcholine Precursor Cells, B-Lymphoid

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