A neural circuit framework for somatosensory amplification in somatoform disorders.

Perez DL, Barsky AJ, Vago DR, Baslet G, Silbersweig DA
J Neuropsychiatry Clin Neurosci. 2015 27 (1): e40-50

PMID: 25716493 · DOI:10.1176/appi.neuropsych.13070170

Although somatosensory amplification is theorized to serve a critical role in somatization, it remains poorly understood neurobiologically. In this perspective article, convergent visceral-somatic processing is highlighted, and neuroimaging studies in somatoform disorders are reviewed. Neural correlates of cognitive-affective amplifiers are integrated into a neurocircuit framework for somatosensory amplification. The anterior cingulate cortex, insula, amygdala, hippocampal formation, and striatum are some of the identified regions. Clinical symptomatology in a given patient or group may represent dysfunction in one or more of these neurobehavioral nodes. Somatosensory amplification may, in part, develop through stress-mediated aberrant neuroplastic changes and the neuromodulatory effects of inflammation.

MeSH Terms (7)

Brain Mapping Female Humans Male Nerve Net Somatoform Disorders Somatosensory Cortex

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