Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

Martín-Martín ML, Bartolomé-Nebreda JM, Conde-Ceide S, Alonso de Diego SA, López S, Martínez-Viturro CM, Tong HM, Lavreysen H, Macdonald GJ, Steckler T, Mackie C, Bridges TM, Daniels JS, Niswender CM, Noetzel MJ, Jones CK, Conn PJ, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2015 25 (6): 1310-7

PMID: 25683622 · PMCID: PMC4399811 · DOI:10.1016/j.bmcl.2015.01.038

MeSH Terms (16)

Allosteric Regulation Animals Antipsychotic Agents Brain Drug Evaluation, Preclinical Half-Life Heterocyclic Compounds, 2-Ring Humans Imidazoles Locomotion Microsomes, Liver Protein Binding Pyrimidinones Rats Receptor, Metabotropic Glutamate 5 Structure-Activity Relationship

Connections (3)

This publication is referenced by other Labnodes entities:

Links