Restriction fragment polymorphisms of the HLA-DR, HLA-DQ, and insulin gene regions in IDDM: the GAW5 data.

Cox NJ, Gogolin KJ, Horvath VJ, Barker DF, Wright E, Tran T, Skolnick MH, Boehm BO, Fehsel K, Bertrams J
Genet Epidemiol. 1989 6 (1): 21-6

PMID: 2567259 · DOI:10.1002/gepi.1370060106

The primary aim of the insulin-dependent diabetes mellitus (IDDM) component of Genetic Analysis Workshop 5 (GAW5) was to collect and analyze new data on DNA polymorphisms closely linked to the HLA-D region and the insulin gene. The probes and restriction enzymes described here were used by all ten participating labs, and the data from Southern blotting were interpreted and reported according to conventions developed for the Workshop. These DNA data on members of 94 families with two or more IDDM sibs constitute the largest such sample available. The data were used in most of the analyses presented at the Workshop meeting, and are available on request.

MeSH Terms (14)

Chromosome Mapping Chromosomes, Human, Pair 6 Chromosomes, Human, Pair 11 Diabetes Mellitus, Type 1 Epidemiologic Methods Europe Genes, Regulator HLA-DQ Antigens HLA-DR Antigens Humans Insulin Multicenter Studies as Topic North America Polymorphism, Restriction Fragment Length

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