EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling.

Lu A, Zuo C, He Y, Chen G, Piao L, Zhang J, Xiao B, Shen Y, Tang J, Kong D, Alberti S, Chen D, Zuo S, Zhang Q, Yan S, Fei X, Yuan F, Zhou B, Duan S, Yu Y, Lazarus M, Su Y, Breyer RM, Funk CD, Yu Y
J Clin Invest. 2015 125 (3): 1228-42

PMID: 25664856 · PMCID: PMC4362262 · DOI:10.1172/JCI77656

MeSH Terms (18)

Animals Cell Hypoxia Cells, Cultured Extracellular Matrix Extracellular Matrix Proteins Hypertension, Pulmonary Male Mice, Inbred C57BL Mice, Knockout Pulmonary Artery Rats, Sprague-Dawley Receptors, Prostaglandin E, EP3 Subtype rhoA GTP-Binding Protein rho GTP-Binding Proteins Signal Transduction Sulfonamides Transforming Growth Factor beta1 Vascular Remodeling

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