Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior.

Jones JR, Tackenberg MC, McMahon DG
Nat Neurosci. 2015 18 (3): 373-5

PMID: 25643294 · PMCID: PMC4502919 · DOI:10.1038/nn.3937

To examine the interaction between molecular, electrical and behavioral circadian rhythms, we combined optogenetic manipulation of suprachiasmatic nucleus (SCN) firing rate with bioluminescence imaging and locomotor activity monitoring. Manipulating firing rate reset circadian rhythms both ex vivo and in vivo, and this resetting required spikes and network communication. This suggests that SCN firing rate is fundamental to circadian pacemaking as both an input to and output of the molecular clockworks.

MeSH Terms (20)

Action Potentials Animals Channelrhodopsins Circadian Rhythm In Vitro Techniques Luminescent Proteins Mice Mice, Inbred C57BL Mice, Transgenic Motor Activity Neurons Patch-Clamp Techniques Period Circadian Proteins Photic Stimulation Receptors, Dopamine D1 Sodium Channel Blockers Suprachiasmatic Nucleus Tetrodotoxin Time Factors Vasoactive Intestinal Peptide

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