Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice.

Dixit S, Bernardo A, Walker JM, Kennard JA, Kim GY, Kessler ES, Harrison FE
ACS Chem Neurosci. 2015 6 (4): 570-81

PMID: 25642732 · PMCID: PMC4476071 · DOI:10.1021/cn500308h

MeSH Terms (21)

Aging Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Anxiety Ascorbic Acid Ascorbic Acid Deficiency Brain Cognition Disorders Disease Models, Animal Female Learning Male Memory Mice, Transgenic Motor Activity Oxidative Stress Peptide Fragments Presenilin-1 Sodium-Coupled Vitamin C Transporters

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