Serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates the longitudinal impact of early caregiving on externalizing behavior.

Brett ZH, Humphreys KL, Smyke AT, Gleason MM, Nelson CA, Zeanah CH, Fox NA, Drury SS
Dev Psychopathol. 2015 27 (1): 7-18

PMID: 25640827 · PMCID: PMC4315507 · DOI:10.1017/S0954579414001266

We examined caregiver report of externalizing behavior from 12 to 54 months of age in 102 children randomized to care as usual in institutions or to newly created high-quality foster care. At baseline no differences by group or genotype in externalizing were found. However, changes in externalizing from baseline to 42 months of age were moderated by the serotonin transporter linked polymorphic region genotype and intervention group, where the slope for short-short (S/S) individuals differed as a function of intervention group. The slope for individuals carrying the long allele did not significantly differ between groups. At 54 months of age, S/S children in the foster care group had the lowest levels of externalizing behavior, while children with the S/S genotype in the care as usual group demonstrated the highest rates of externalizing behavior. No intervention group differences were found in externalizing behavior among children who carried the long allele. These findings, within a randomized controlled trial of foster care compared to continued care as usual, indicate that the serotonin transporter linked polymorphic region genotype moderates the relation between early caregiving environments to predict externalizing behavior in children exposed to early institutional care in a manner most consistent with differential susceptibility.

MeSH Terms (18)

Alleles Caregivers Child Child, Institutionalized Child, Preschool Child Behavior Disorders Female Foster Home Care Gene-Environment Interaction Genetic Predisposition to Disease Genotype Humans Infant Internal-External Control Longitudinal Studies Male Polymorphism, Genetic Serotonin Plasma Membrane Transport Proteins

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