Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction.

Moriceau G, Hugo W, Hong A, Shi H, Kong X, Yu CC, Koya RC, Samatar AA, Khanlou N, Braun J, Ruchalski K, Seifert H, Larkin J, Dahlman KB, Johnson DB, Algazi A, Sosman JA, Ribas A, Lo RS
Cancer Cell. 2015 27 (2): 240-56

PMID: 25600339 · PMCID: PMC4326539 · DOI:10.1016/j.ccell.2014.11.018

MeSH Terms (9)

Cell Line, Tumor Drug Resistance, Neoplasm Humans MAP Kinase Signaling System Melanoma Molecular Targeted Therapy Mutation Protein Kinase Inhibitors Proto-Oncogene Proteins B-raf

Connections (1)

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