MiRNA inhibition in tissue engineering and regenerative medicine.

Beavers KR, Nelson CE, Duvall CL
Adv Drug Deliv Rev. 2015 88: 123-37

PMID: 25553957 · PMCID: PMC4485980 · DOI:10.1016/j.addr.2014.12.006

MicroRNAs (miRNAs) are noncoding RNAs that provide an endogenous negative feedback mechanism for translation of messenger RNA (mRNA) into protein. Single miRNAs can regulate hundreds of mRNAs, enabling miRNAs to orchestrate robust biological responses by simultaneously impacting multiple gene networks. MiRNAs can act as master regulators of normal and pathological tissue development, homeostasis, and repair, which has motivated expanding efforts toward the development of technologies for therapeutically modulating miRNA activity for regenerative medicine and tissue engineering applications. This review highlights the tools currently available for miRNA inhibition and their recent therapeutic applications for improving tissue repair.

Copyright © 2014 Elsevier B.V. All rights reserved.

MeSH Terms (17)

Bone and Bones Cicatrix Genetic Vectors Humans Inflammation Kidney Liver MicroRNAs Muscle, Skeletal Myocardium Neovascularization, Pathologic Regeneration Regenerative Medicine RNA, Messenger Tissue Engineering Tissue Scaffolds Wound Healing

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