Long-range GABAergic neurons in the prefrontal cortex modulate behavior.

Bravo-Rivera C, Diehl MM, Roman-Ortiz C, Rodriguez-Romaguera J, Rosas-Vidal LE, Bravo-Rivera H, Quiñones-Laracuente K, Do-Monte FH
J Neurophysiol. 2015 114 (3): 1357-9

PMID: 25520436 · PMCID: PMC4556857 · DOI:10.1152/jn.00861.2014

Cortical glutamatergic projections are extensively studied in behavioral neuroscience, whereas cortical GABAergic projections to downstream structures have been overlooked. A recent study by Lee and colleagues (Lee AT, Vogt D, Rubenstein JL, Sohal VS. J Neurosci 34: 11519-11525, 2014) used optogenetic and electrophysiological techniques to characterize a behavioral role for long-projecting GABAergic neurons in the medial prefrontal cortex. In this Neuro Forum, we discuss the potential implications of this study in several learning and memory models.

Copyright © 2015 the American Physiological Society.

MeSH Terms (8)

Animals Avoidance Learning Female GABAergic Neurons Male Neural Pathways Nucleus Accumbens Prefrontal Cortex

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