A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo.

Brezski RJ, Kinder M, Grugan KD, Soring KL, Carton J, Greenplate AR, Petley T, Capaldi D, Brosnan K, Emmell E, Watson S, Jordan RE
MAbs. 2014 6 (5): 1265-73

PMID: 25517311 · PMCID: PMC4623506 · DOI:10.4161/mabs.29825

MeSH Terms (20)

Animals Antibodies, Monoclonal Antibodies, Monoclonal, Murine-Derived Antibody-Dependent Cell Cytotoxicity Bacterial Proteins Blood Platelets Cell Line Cell Line, Tumor Cysteine Endopeptidases Dogs Enzyme-Linked Immunosorbent Assay Epitopes Humans Immunoglobulin Fab Fragments Immunoglobulin G Matrix Metalloproteinase 3 Platelet Count Proteolysis Rats Rituximab

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