PIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancer.

Kirschner AN, Wang J, van der Meer R, Anderson PD, Franco-Coronel OE, Kushner MH, Everett JH, Hameed O, Keeton EK, Ahdesmaki M, Grosskurth SE, Huszar D, Abdulkadir SA
J Natl Cancer Inst. 2015 107 (2)

PMID: 25505253 · PMCID: PMC4326311 · DOI:10.1093/jnci/dju407

MeSH Terms (22)

Administration, Oral Allografts Animals Antineoplastic Agents Apoptosis Biphenyl Compounds Cell Hypoxia Cell Proliferation Down-Regulation Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Genes, myc Humans Male Mice Prostatic Neoplasms Prostatic Neoplasms, Castration-Resistant Protein Kinase Inhibitors Proto-Oncogene Proteins c-pim-1 Thiazolidines Tumor Suppressor Protein p53 Xenograft Model Antitumor Assays

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