Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.

Han C, Chatterjee A, Noetzel MJ, Panarese JD, Smith E, Chase P, Hodder P, Niswender C, Conn PJ, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2015 25 (2): 384-8

PMID: 25435150 · PMCID: PMC4278958 · DOI:10.1016/j.bmcl.2014.11.011

MeSH Terms (13)

Allosteric Regulation Allosteric Site Drug Discovery Humans Models, Molecular Molecular Docking Simulation Molecular Structure Pyrazoles Quinolines Quinolones Receptor, Muscarinic M1 Small Molecule Libraries Structure-Activity Relationship

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