Shaping the intestinal brush border.

Crawley SW, Mooseker MS, Tyska MJ
J Cell Biol. 2014 207 (4): 441-51

PMID: 25422372 · PMCID: PMC4242837 · DOI:10.1083/jcb.201407015

Epithelial cells from diverse tissues, including the enterocytes that line the intestinal tract, remodel their apical surface during differentiation to form a brush border: an array of actin-supported membrane protrusions known as microvilli that increases the functional capacity of the tissue. Although our understanding of how epithelial cells assemble, stabilize, and organize apical microvilli is still developing, investigations of the biochemical and physical underpinnings of these processes suggest that cells coordinate cytoskeletal remodeling, membrane-cytoskeleton cross-linking, and extracellular adhesion to shape the apical brush border domain.

© 2014 Crawley et al.

MeSH Terms (11)

Animals Cell Differentiation Cytoskeletal Proteins Cytoskeleton Enterocytes Humans Intestines Mice Microvilli Myosin Heavy Chains Myosin Type I

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