Biophysical analysis of dystrophic and osteogenic models of valvular calcification.

Chen J, Peacock JR, Branch J, David Merryman W
J Biomech Eng. 2015 137 (2): 020903

PMID: 25405546 · PMCID: PMC4321106 · DOI:10.1115/1.4029115

Calcific aortic valve disease (CAVD) is a significant cardiovascular disorder characterized by the formation of calcific nodules (CN) on the valve. In vitro assays studying the formation of these nodules were developed and have led to many significant mechanistic findings; however, the biophysical properties of CNs have not been clearly defined. A thorough analysis of dystrophic and osteogenic nodules utilizing scanning electron microscopy (SEM), energy dispersive spectrometry (EDS), and atomic force microscopy (AFM) was conducted to describe calcific nodule properties and provide a link between calcific nodule morphogenesis in vitro and in vivo. Unique nodule properties were observed for dystrophic and osteogenic nodules, highlighting the distinct mechanisms occurring in valvular calcification.

MeSH Terms (11)

Animals Aortic Valve Aortic Valve Stenosis Biomechanical Phenomena Calcinosis Calcium Cell Survival Models, Biological Osteogenesis Phosphorus Swine

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