Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells.

Vilgelm AE, Pawlikowski JS, Liu Y, Hawkins OE, Davis TA, Smith J, Weller KP, Horton LW, McClain CM, Ayers GD, Turner DC, Essaka DC, Stewart CF, Sosman JA, Kelley MC, Ecsedy JA, Johnston JN, Richmond A
Cancer Res. 2015 75 (1): 181-93

PMID: 25398437 · PMCID: PMC4286469 · DOI:10.1158/0008-5472.CAN-14-2405

MeSH Terms (17)

Animals Antineoplastic Combined Chemotherapy Protocols Apoptosis Aurora Kinase A Azepines Cell Proliferation Humans Imidazoles Melanoma Melanoma, Experimental Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Piperazines Protein Kinase Inhibitors Proto-Oncogene Proteins c-mdm2 Pyrimidines

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