Toward primary prevention of asthma. Reviewing the evidence for early-life respiratory viral infections as modifiable risk factors to prevent childhood asthma.

Feldman AS, He Y, Moore ML, Hershenson MB, Hartert TV
Am J Respir Crit Care Med. 2015 191 (1): 34-44

PMID: 25369458 · PMCID: PMC4299628 · DOI:10.1164/rccm.201405-0901PP

A first step in primary disease prevention is identifying common, modifiable risk factors that contribute to a significant proportion of disease development. Infant respiratory viral infection and childhood asthma are the most common acute and chronic diseases of childhood, respectively. Common clinical features and links between these diseases have long been recognized, with early-life respiratory syncytial virus (RSV) and rhinovirus (RV) lower respiratory tract infections (LRTIs) being strongly associated with increased asthma risk. However, there has long been debate over the role of these respiratory viruses in asthma inception. In this article, we systematically review the evidence linking early-life RSV and RV LRTIs with asthma inception and whether they could therefore be targets for primary prevention efforts.

MeSH Terms (20)

Antibodies, Monoclonal, Humanized Antiviral Agents Asthma Child, Preschool Diet Environmental Exposure Epigenesis, Genetic Genetic Predisposition to Disease Humans Infant Microbiota Palivizumab Primary Prevention Respiratory Syncytial Viruses Respiratory Syncytial Virus Infections Respiratory Tract Infections Rhinovirus Risk Factors Severity of Illness Index Tobacco Smoke Pollution

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