Anti-remodeling and anti-fibrotic effects of the neuregulin-1β glial growth factor 2 in a large animal model of heart failure.

Galindo CL, Kasasbeh E, Murphy A, Ryzhov S, Lenihan S, Ahmad FA, Williams P, Nunnally A, Adcock J, Song Y, Harrell FE, Tran TL, Parry TJ, Iaci J, Ganguly A, Feoktistov I, Stephenson MK, Caggiano AO, Sawyer DB, Cleator JH
J Am Heart Assoc. 2014 3 (5): e000773

PMID: 25341890 · PMCID: PMC4323814 · DOI:10.1161/JAHA.113.000773

MeSH Terms (22)

Actins Animals Cells, Cultured Disease Models, Animal Dose-Response Relationship, Drug Fibrosis Gene Expression Regulation Heart Failure Male Mice, Inbred C57BL Myocardial Contraction Myocardium Myofibroblasts Neuregulin-1 Phosphorylation Rats, Sprague-Dawley Smad3 Protein Swine Time Factors Transcription, Genetic Ventricular Function, Left Ventricular Remodeling

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