The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation.

DiGiandomenico A, Veach RA, Zienkiewicz J, Moore DJ, Wylezinski LS, Hutchens MA, Hawiger J
PLoS One. 2014 9 (10): e110183

PMID: 25329889 · PMCID: PMC4203769 · DOI:10.1371/journal.pone.0110183

MeSH Terms (16)

Active Transport, Cell Nucleus Animals Bone Marrow Cells Cell-Penetrating Peptides Cell Nucleus Chemokines Gene Expression Regulation Genome, Human Humans Lipopolysaccharides Macrophages Mice Pneumonia Shock, Septic Transcription Factors Transcriptome

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