Calcium in atrial fibrillation - pulling the trigger or not?

Gomez-Hurtado N, Knollmann BC
J Clin Invest. 2014 124 (11): 4684-6

PMID: 25329688 · PMCID: PMC4347245 · DOI:10.1172/JCI77986

Atrial fibrillation (AF) is the most common sustained arrhythmia disease. Current drug- and surgical-based therapies are ineffective in about 40% to 50% of AF patients; therefore, there is a great need to better understand the underlying mechanisms of this disease and identify potential therapeutic targets. In this issue of the JCI, Greiser and coworkers discovered that atrial remodeling in response to sustained tachycardia silences Ca2+ signaling in isolated rabbit and human atrial myocytes. This Ca2+ release silencing was attributable to a failure of subcellular propagated Ca2+ release due to an increased cytosolic buffering strength. The results from this study challenge the current paradigm that Ca2+ release instability underlies AF. Instead, Ca2+ silencing could be protective against the massive cellular Ca2+ loading that occurs during chronic AF.

MeSH Terms (6)

Animals Calcium Signaling Heart Atria Humans Myocytes, Cardiac Tachycardia

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