Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor.

Shi J, Zhou J, Halambage UD, Shah VB, Burse MJ, Wu H, Blair WS, Butler SL, Aiken C
J Virol. 2015 89 (1): 208-19

PMID: 25320302 · PMCID: PMC4301104 · DOI:10.1128/JVI.01411-14

MeSH Terms (15)

Amino Acid Substitution Anti-HIV Agents Cells, Cultured Drug Resistance, Viral HIV-1 HIV Core Protein p24 Humans Indoles Macrophages Mutant Proteins Mutation, Missense Phenylalanine Selection, Genetic Suppression, Genetic Virus Replication

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