PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.

Wu CY, Carpenter ES, Takeuchi KK, Halbrook CJ, Peverley LV, Bien H, Hall JC, DelGiorno KE, Pal D, Song Y, Shi C, Lin RZ, Crawford HC
Gastroenterology. 2014 147 (6): 1405-16.e7

PMID: 25311989 · PMCID: PMC4252806 · DOI:10.1053/j.gastro.2014.08.032

MeSH Terms (19)

Acinar Cells Adenocarcinoma Animals Carcinogenesis Carcinoma, Pancreatic Ductal Cell Transformation, Neoplastic Class I Phosphatidylinositol 3-Kinases Cytoskeleton Female Humans Male Mice, Mutant Strains Neuropeptides Phosphatidylinositol 3-Kinases Primary Cell Culture Proto-Oncogene Proteins p21(ras) rac1 GTP-Binding Protein Signal Transduction Transcriptome

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