The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III.

Jacobson R, Mignemi N, Rose K, O'Rear L, Sarilla S, Hamm HE, Barnett JV, Verhamme IM, Schoenecker J
Thromb Res. 2014 134 (6): 1350-7

PMID: 25307422 · PMCID: PMC4337957 · DOI:10.1016/j.thromres.2014.09.038

MeSH Terms (9)

Anticoagulants Antithrombin III Blood Coagulation Dose-Response Relationship, Drug Heparin Humans Hyperglycemia Protein Binding Pyruvaldehyde

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