P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.

Dillon LM, Bean JR, Yang W, Shee K, Symonds LK, Balko JM, McDonald WH, Liu S, Gonzalez-Angulo AM, Mills GB, Arteaga CL, Miller TW
Oncogene. 2015 34 (30): 3968-76

PMID: 25284585 · PMCID: PMC4387124 · DOI:10.1038/onc.2014.328

MeSH Terms (17)

Animals Breast Neoplasms Cell Survival Feedback, Physiological Female Guanine Nucleotide Exchange Factors Humans MAP Kinase Signaling System MCF-7 Cells Mice, Inbred NOD Mice, SCID Mutation Neoplasm Transplantation Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins c-akt rac GTP-Binding Proteins Receptors, Growth Factor

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