A polymorphism in HLA-G modifies statin benefit in asthma.

Naidoo D, Wu AC, Brilliant MH, Denny J, Ingram C, Kitchner TE, Linneman JG, McGeachie MJ, Roden DM, Shaffer CM, Shah A, Weeke P, Weiss ST, Xu H, Medina MW
Pharmacogenomics J. 2015 15 (3): 272-7

PMID: 25266681 · PMCID: PMC4379135 · DOI:10.1038/tpj.2014.55

Several reports have shown that statin treatment benefits patients with asthma; however, inconsistent effects have been observed. The mir-152 family (148a, 148b and 152) has been implicated in asthma. These microRNAs suppress HLA-G expression, and rs1063320, a common SNP in the HLA-G 3'UTR that is associated with asthma risk, modulates miRNA binding. We report that statins upregulate mir-148b and 152, and affect HLA-G expression in an rs1063320-dependent fashion. In addition, we found that individuals who carried the G minor allele of rs1063320 had reduced asthma-related exacerbations (emergency department visits, hospitalizations or oral steroid use) compared with non-carriers (P=0.03) in statin users ascertained in the Personalized Medicine Research Project at the Marshfield Clinic (n=421). These findings support the hypothesis that rs1063320 modifies the effect of statin benefit in asthma, and thus may contribute to variation in statin efficacy for the management of this disease.

MeSH Terms (14)

3' Untranslated Regions Alleles Asthma Cell Line, Tumor Female Hep G2 Cells HLA-G Antigens Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Male MicroRNAs Middle Aged Polymorphism, Single Nucleotide Risk

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