Discovery of potent and selective GIRK1/2 modulators via 'molecular switches' within a series of 1-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)ureas.

Wen W, Wu W, Weaver CD, Lindsley CW
Bioorg Med Chem Lett. 2014 24 (21): 5102-6

PMID: 25264075 · DOI:10.1016/j.bmcl.2014.08.061

MeSH Terms (10)

Animals Drug Evaluation, Preclinical G Protein-Coupled Inwardly-Rectifying Potassium Channels Microsomes Phenylurea Compounds Protein Binding Pyrazoles Rats Structure-Activity Relationship Urea

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