Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles.

Rook JM, Tantawy MN, Ansari MS, Felts AS, Stauffer SR, Emmitte KA, Kessler RM, Niswender CM, Daniels JS, Jones CK, Lindsley CW, Conn PJ
Neuropsychopharmacology. 2015 40 (3): 755-65

PMID: 25241804 · PMCID: PMC4289965 · DOI:10.1038/npp.2014.245

MeSH Terms (21)

Allosteric Regulation Amphetamine Animals Benzamides Calcium Cerebellum Corpus Striatum Dose-Response Relationship, Drug HEK293 Cells Humans Locomotion Male Maze Learning Niacinamide Piperidines Positron-Emission Tomography Radioligand Assay Rats Receptor, Metabotropic Glutamate 5 Structure-Activity Relationship Thiazoles

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