Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7.

Jalan-Sakrikar N, Field JR, Klar R, Mattmann ME, Gregory KJ, Zamorano R, Engers DW, Bollinger SR, Weaver CD, Days EL, Lewis LM, Utley TJ, Hurtado M, Rigault D, Acher F, Walker AG, Melancon BJ, Wood MR, Lindsley CW, Conn PJ, Xiang Z, Hopkins CR, Niswender CM
ACS Chem Neurosci. 2014 5 (12): 1221-37

PMID: 25225882 · PMCID: PMC4306484 · DOI:10.1021/cn500153z

MeSH Terms (26)

Acetanilides Animals Benzoates Calcium CHO Cells Cricetulus Dose-Response Relationship, Drug Excitatory Amino Acid Agents Excitatory Postsynaptic Potentials Glutamic Acid Glycine G Protein-Coupled Inwardly-Rectifying Potassium Channels HEK293 Cells Hippocampus Humans In Vitro Techniques Male Mice, Inbred C57BL Picolinic Acids Propionates Pyrroles Rats Receptors, Metabotropic Glutamate Structure-Activity Relationship Thallium Transfection

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