Pharmacological management of fluid overload.

Goldstein S, Bagshaw S, Cecconi M, Okusa M, Wang H, Kellum J, Mythen M, Shaw AD, ADQI XII Investigators Group
Br J Anaesth. 2014 113 (5): 756-63

PMID: 25209097 · DOI:10.1093/bja/aeu299

BACKGROUND - Standard treatment practice for the hypotensive patient with poor tissue perfusion is rapid volume resuscitation; in some scenarios, such as septic shock, this is performed with targeted goal-directed endpoints within 6 h of presentation. As a result, patients often develop significant positive fluid accumulation, which has been associated with poor outcomes above certain thresholds.

METHODS - The aim of the current paper is to provide guidance for active pharmacological fluid management in the patient with, or at risk for, clinically significant positive fluid balance from either resuscitation for hypovolaemic shock or acute decompensated heart failure.

RESULTS - We develop rationale for pharmacological fluid management targets (prevention of worsening fluid accumulation, achievement of slow vs rapid net negative fluid balance) in the context of phases of critical illness provided in the earlier Acute Dialysis Quality Initiative 12 papers.

© The Author 2014. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email:

MeSH Terms (10)

Critical Care Delphi Technique Diuretics Fluid Therapy Heart Failure Humans Perfusion Resuscitation Shock Water-Electrolyte Imbalance

Connections (1)

This publication is referenced by other Labnodes entities: