Small molecule Mcl-1 inhibitors for the treatment of cancer.

Belmar J, Fesik SW
Pharmacol Ther. 2015 145: 76-84

PMID: 25172548 · PMCID: PMC4340597 · DOI:10.1016/j.pharmthera.2014.08.003

The Bcl-2 family of proteins serves as primary regulators of apoptosis. Myeloid cell leukemia 1 (Mcl-1), a pro-survival member of the Bcl-2 family of proteins, is overexpressed and the Mcl-1 gene is amplified in many tumor types. Moreover, the overexpression of Mcl-1 is the cause of resistance to several chemotherapeutic agents. Thus, Mcl-1 is a promising cancer target. This review highlights the current progress on the discovery of small molecule Mcl-1 inhibitors.

Copyright © 2014 Elsevier Inc. All rights reserved.

MeSH Terms (4)

Antineoplastic Agents Humans Myeloid Cell Leukemia Sequence 1 Protein Neoplasms

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