Increased hippocampal CA1 cerebral blood volume in schizophrenia.

Talati P, Rane S, Kose S, Blackford JU, Gore J, Donahue MJ, Heckers S
Neuroimage Clin. 2014 5: 359-64

PMID: 25161901 · PMCID: PMC4141978 · DOI:10.1016/j.nicl.2014.07.004

Hippocampal hyperactivity has been proposed as a biomarker in schizophrenia. However, there is a debate whether the CA1 or the CA2/3 subfield is selectively affected. We studied 15 schizophrenia patients and 15 matched healthy control subjects with 3T steady state, gadolinium-enhanced, absolute cerebral blood volume (CBV) maps, perpendicular to the long axis of the hippocampus. The subfields of the hippocampal formation (subiculum, CA1, CA2/3, and hilus/dentate gyrus) were manually segmented to establish CBV values. Comparing anterior CA1 and CA2/3 CBV between patients and controls revealed a significant subfield-by-diagnosis interaction. This interaction was due to the combined effect of a trend of increased CA1 CBV (p = .06) and non-significantly decreased CA2/3 CBV (p = 0.14) in patients relative to healthy controls. These results support the emerging hypothesis of increased hippocampal activity as a biomarker of schizophrenia and highlight the importance of subfield-level investigations.

MeSH Terms (9)

Adult Blood Volume CA1 Region, Hippocampal Female Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Male Schizophrenia

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