Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain.

Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL
Proc Natl Acad Sci U S A. 2014 111 (36): 13046-51

PMID: 25157167 · PMCID: PMC4246986 · DOI:10.1073/pnas.1406050111

MeSH Terms (18)

Activating Transcription Factor 6 Amyloid DNA-Binding Proteins Extracellular Space Genes, Reporter HEK293 Cells Humans Immunoglobulin Light Chains Luciferases Protein Aggregates Protein Stability Proteolysis Regulatory Factor X Transcription Factors Stress, Physiological Thapsigargin Transcription Factors Unfolded Protein Response X-Box Binding Protein 1

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