Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.

Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB, GoT2D Consortium, NHGRI JHS/FHS Allelic Spectrum Project, SIGMA T2D Consortium, T2D-GENES Consortium, Rosen ED, Altshuler D
Proc Natl Acad Sci U S A. 2014 111 (36): 13127-32

PMID: 25157153 · PMCID: PMC4246964 · DOI:10.1073/pnas.1410428111

MeSH Terms (17)

Adipocytes Adult Aged Aged, 80 and over Case-Control Studies Cell Differentiation Diabetes Mellitus, Type 2 Ethnic Groups Female Genetic Predisposition to Disease Humans Male Middle Aged Polymorphism, Single Nucleotide PPAR gamma Risk Factors Sequence Analysis, DNA

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