Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.

Bubser M, Bridges TM, Dencker D, Gould RW, Grannan M, Noetzel MJ, Lamsal A, Niswender CM, Daniels JS, Poslusney MS, Melancon BJ, Tarr JC, Byers FW, Wess J, Duggan ME, Dunlop J, Wood MW, Brandon NJ, Wood MR, Lindsley CW, Conn PJ, Jones CK
ACS Chem Neurosci. 2014 5 (10): 920-42

PMID: 25137629 · PMCID: PMC4324418 · DOI:10.1021/cn500128b

MeSH Terms (24)

Amphetamines Animals Association Learning Brain Cell Line Central Nervous System Stimulants Cholinergic Agents Cricetulus Dizocilpine Maleate Dogs Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists Humans Macaca fascicularis Male Mice, Inbred C57BL Mice, Knockout Motor Activity Psychotropic Drugs Pyridazines Rats Rats, Sprague-Dawley Receptor, Muscarinic M4 Thiophenes

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