Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics.

Cho HP, Garcia-Barrantes PM, Brogan JT, Hopkins CR, Niswender CM, Rodriguez AL, Venable DF, Morrison RD, Bubser M, Daniels JS, Jones CK, Conn PJ, Lindsley CW
ACS Chem Biol. 2014 9 (10): 2334-46

PMID: 25137254 · PMCID: PMC4201332 · DOI:10.1021/cb500560h

MeSH Terms (19)

Allosteric Regulation Animals Calcium Chromatography, Liquid Genome-Wide Association Study Glutamic Acid HEK293 Cells Humans Locomotion Male Microsomes, Liver Molecular Structure Mutation Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate Schizophrenia Small Molecule Libraries Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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