Publication

PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors.

Lehmann BD, Bauer JA, Schafer JM, Pendleton CS, Tang L, Johnson KC, Chen X, Balko JM, Gómez H, Arteaga CL, Mills GB, Sanders ME, Pietenpol JA
Breast Cancer Res. 2014 16 (4): 406

PMID: 25103565 · PMCID: PMC4187324 · DOI:10.1186/s13058-014-0406-x

MeSH Terms (23)

Androgen Receptor Antagonists Animals Antineoplastic Agents Cell Line, Tumor Cell Survival Class I Phosphatidylinositol 3-Kinases Cluster Analysis Dihydrotestosterone Disease Models, Animal Drug Resistance, Neoplasm Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Mutation Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Protein Kinase Inhibitors Receptors, Androgen Signal Transduction TOR Serine-Threonine Kinases Triple Negative Breast Neoplasms Xenograft Model Antitumor Assays

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