Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.

Shimada T, Martin MV, Pruess-Schwartz D, Marnett LJ, Guengerich FP
Cancer Res. 1989 49 (22): 6304-12

PMID: 2509067

MeSH Terms (17)

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Animals Benzo(a)pyrene Biotransformation Cytochrome P-450 Enzyme System Dihydroxydihydrobenzopyrenes DNA Damage Gene Expression Genes Humans Isoenzymes Kinetics Lung Microsomes Microsomes, Liver Polycyclic Compounds Rats

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