Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling.

Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS
J Allergy Clin Immunol. 2014 134 (3): 698-705.e5

PMID: 25042746 · PMCID: PMC4358822 · DOI:10.1016/j.jaci.2014.06.004

MeSH Terms (18)

Air Pollution Allergens Animals Enzyme Inhibitors Epoprostenol Humans Hypersensitivity Immune Tolerance Indomethacin Mice Mice, 129 Strain Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Ovalbumin Prostaglandin-Endoperoxide Synthases Receptors, Epoprostenol Signal Transduction

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