Pyrvinium attenuates Hedgehog signaling downstream of smoothened.

Li B, Fei DL, Flaveny CA, Dahmane N, Baubet V, Wang Z, Bai F, Pei XH, Rodriguez-Blanco J, Hang B, Orton D, Han L, Wang B, Capobianco AJ, Lee E, Robbins DJ
Cancer Res. 2014 74 (17): 4811-21

PMID: 24994715 · PMCID: PMC4321822 · DOI:10.1158/0008-5472.CAN-14-0317

MeSH Terms (18)

Animals Carcinoma, Basal Cell Casein Kinase Ialpha Cell Line Hedgehog Proteins HEK293 Cells Humans Medulloblastoma Mice Mice, Nude NIH 3T3 Cells Oncogene Proteins Pyrvinium Compounds Receptors, G-Protein-Coupled Signal Transduction Trans-Activators Transcription Factors Zinc Finger Protein GLI1

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