Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.

Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG, Zhang Q
Genes Dev. 2014 28 (13): 1429-44

PMID: 24990963 · PMCID: PMC4083087 · DOI:10.1101/gad.242131.114

MeSH Terms (14)

Animals Cell Line Cells, Cultured Cyclin D1 Forkhead Box Protein O3 Forkhead Transcription Factors Gene Expression Regulation, Neoplastic Hydroxylation Hypoxia-Inducible Factor-Proline Dioxygenases MCF-7 Cells Mice Protein Binding Protein Stability Ubiquitin Thiolesterase

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