Intricate protein-protein interactions in the cyanobacterial circadian clock.

Egli M
J Biol Chem. 2014 289 (31): 21267-75

PMID: 24936066 · PMCID: PMC4118088 · DOI:10.1074/jbc.R114.579607

The cyanobacterial circadian clock consists of a post-translational oscillator (PTO) and a PTO-dependent transcription-translation feedback loop (TTFL). The PTO can be reconstituted in vitro with the KaiA, KaiB, and KaiC proteins, enabling detailed biochemical and biophysical investigations. Both the CI and the CII halves of the KaiC hexamer harbor ATPases, but only the C-terminal CII ring exhibits kinase and phospho-transferase activities. KaiA stimulates the kinase and KaiB associates with KaiC during the dephosphorylation phase and sequesters KaiA. Recent research has led to conflicting models of the KaiB-KaiC interaction, precluding a clear understanding of KaiB function and KaiABC clock mechanism.

© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

MeSH Terms (8)

Amino Acid Sequence Bacterial Proteins Circadian Clocks Cyanobacteria Molecular Sequence Data Phosphorylation Protein Binding Protein Conformation

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