STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.

Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE, Boyd KL, Moore ML, Zhou W, Peebles RS
J Virol. 2014 88 (17): 9655-72

PMID: 24920804 · PMCID: PMC4136353 · DOI:10.1128/JVI.03299-13

MeSH Terms (12)

Animals CD8-Positive T-Lymphocytes Disease Models, Animal Female Lung Mice, Inbred BALB C Mice, Knockout Respiratory Syncytial Viruses Respiratory Syncytial Virus Infections STAT4 Transcription Factor Th2 Cells Th17 Cells

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