Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).

Turlington M, Malosh C, Jacobs J, Manka JT, Noetzel MJ, Vinson PN, Jadhav S, Herman EJ, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martín-Martín ML, Tong HM, López S, MacDonald GJ, Steckler T, Daniels JS, Weaver CD, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Stauffer SR
J Med Chem. 2014 57 (13): 5620-37

PMID: 24914612 · PMCID: PMC4096224 · DOI:10.1021/jm500259z

MeSH Terms (11)

Allosteric Regulation Animals Antipsychotic Agents HEK293 Cells Humans Microsomes, Liver Naphthyridines Rats Receptor, Metabotropic Glutamate 5 Schizophrenia Structure-Activity Relationship

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