L-citrulline provides a novel strategy for treating chronic pulmonary hypertension in newborn infants.

Fike CD, Summar M, Aschner JL
Acta Paediatr. 2014 103 (10): 1019-26

PMID: 24862864 · PMCID: PMC4209175 · DOI:10.1111/apa.12707

UNLABELLED - Effective therapies are urgently needed for infants with forms of pulmonary hypertension that develop or persist beyond the first week of life. The L-arginine nitric oxide (NO) precursor, L-citrulline, improves NO signalling and ameliorates pulmonary hypertension in newborn animals. In vitro studies demonstrate that manipulating L-citrulline transport alters NO production.

CONCLUSION - Strategies that increase the supply and transport of L-citrulline merit pursuit as novel approaches to managing infants with chronic, progressive pulmonary hypertension.

©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

MeSH Terms (12)

Amino Acid Transport Systems, Neutral Animals Cardiovascular Diseases Citrulline Endothelial Cells Humans Hypertension, Pulmonary Hypoxia Infant, Newborn Models, Animal Nitric Oxide Nitric Oxide Synthase Type III

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